Renal Glucosuria: Background, Pathophysiology, Epidemiology. Santer R, Kinner M, Lassen CL, Schneppenheim R, Eggert P, Bald M, et al. Molecular analysis of the SGLT2 gene in patients with renal glucosuria. Calado J, Loeffler J, Sakallioglu O, Gok F, Lhotta K, Barata J, et al. ![]() Familial renal glucosuria: SLC5. A2 mutation analysis and evidence of salt- wasting. Calado J, Sznajer Y, Metzger D, Rita A, Hogan MC, Kattamis A, et al. Twenty- one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. Nephrol Dial Transplant. Calado J, Soto K, Clemente C, Correia P, Rueff J. Novel compound heterozygous mutations in SLC5. A2 are responsible for autosomal recessive renal glucosuria. Familial renal glycosuria and modifications of glucose renal excretion.
Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications. Pediatric nephrology, 5th edn. Philadelphia, PA: Lippincott Williams & Wilkins; 2. Glucose transporters: structure, function and consequences of deficiency. De. Fronzo RA, Davidson JA, Del Prato S. The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia. Calado J, Loeffler J, Sakallioglu O, Gok F, Lhotta K, Barata J. Familial renal glucosuria: SLC5. A2 mutation analysis and evidence of salt- wasting. Calado J, Sznajer Y, Metzger D, Rita A, Hogan MC, Kattamis A. Twenty- one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. Nephrol Dial Transplant. Santer R, Kinner M, Lassen CL, Schneppenheim R, Eggert P, Bald M, et al. Molecular analysis of the SGLT2 gene in patients with renal glucosuria. Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target. Clin J Am Soc Nephrol. Yu L, Lv JC, Zhou XJ, Zhu L, Hou P, Zhang H. Abnormal expression and dysfunction of novel SGLT2 mutations identified in familial renal glucosuria patients. Quamme GA, Freeman HJ. Evidence for a high- affinity sodium- dependent D- glucose transport system in the kidney. Santer R, Kinner M, Lassen CL, et al. Molecular analysis of the SGLT2 gene in patients with renal glucosuria. Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients. The Heart Outcomes Prevention. Insulin but not phlorizin treatment induces a transient increase in GLUT2 gene expression in the kidney of diabetic rats. Magen D, Sprecher E, Zelikovic I, Skorecki K. A novel missense mutation in SLC5. A2 encoding SGLT2 underlies autosomal- recessiverenal glucosuria and aminoaciduria. Kleta R, Stuart C, Gill FA, Gahl WA. Renal glucosuria due to SGLT2 mutations. Oemar BS, Byrd DJ, Brodehl J. Complete absence of tubular glucose reabsorption: a new type of renal glucosuria (type 0). De Paoli P, Battistin S, Jus A, Reitano M, Villalta D, De Marchi S. Immunological characterization of renal glycosuria patients. Renal glucosuria and aminoaciduria. Sankarasubbaiyan S, Cooper C, Heilig CW. Identification of a novel form of renal glucosuria with overexcretion of arginine, carnosine, and taurine. Bingham C, Ellard S, Nicholls AJ, Pennock CA, Allen J, James AJ. The generalized aminoaciduria seen in patients with hepatocyte nuclear factor- 1alpha mutations is a feature of all patients with diabetes and is associated with glucosuria. Santer R, Kinner M, Lassen CL, Schneppenheim R, Eggert P, Bald M. Molecular analysis of the SGLT2 gene in patients with renal glucosuria. Yu L, Lv JC, Zhou XJ, Zhu L, Hou P, Zhang H. Abnormal expression and dysfunction of novel SGLT2 mutations identified in familial renal glucosuria patients. Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target. Clin J Am Soc Nephrol. Turk E, Zabel B, Mundlos S, Dyer J, Wright EM. Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter. Yu L, Hou P, Lv JC, Liu GP, Zhang H. A novel sodium- glucose co- transporter 2 gene (SGLT2) mutation contributes to the abnormal expression of SGLT2 in renal tissues in familial renal glucosuria. The third heart sound or S 3 is a rare extra heart sound that occurs soon after the normal two "lub-dub" heart sounds (S 1 and S 2). S3 is associated with heart failure.Angelopoulos TP, Doupis J. Sodium- Glucose linked transporter 2 (SGLT2) inhibitors- -fighting diabetes from a new perspective. Andrianesis V, Doupis J. The role of kidney in glucose homeostasis- -SGLT2 inhibitors, a new approach in diabetes treatment. Expert Rev Clin Pharmacol. Inhibitors of type 2 sodium glucose co- transporters- -a new strategy for diabetes treatment. Wilding JP, Norwood P, T'joen C, Bastien A, List JF, Fiedorek FT. A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin- independent treatment. Maximal tubular reabsorption of glucose in infants and children. Calado J, Loeffler J, Sakallioglu O, Gok F, Lhotta K, Barata J. Familial renal glucosuria: SLC5. A2 mutation analysis and evidence of salt- wasting. Calado J, Soto K, Clemente C, Correia P, Rueff J. Novel compound heterozygous mutations in SLC5. A2 are responsible for autosomal recessive renal glucosuria. Incidence of glycosuria and diabetes. De Marchi S, Cecchin E, Basile A, Proto G, Donadon W, Schinella D. Is renal glycosuria a benign condition? Proc Eur Dial Transplant Assoc. Desjeuz JF, Turk E, Wright E. Congenital selective Na+ D- glucose co- transport defects leading to renal glycosuria and congenital selective intestinal malabsorption of glucose and galactose. The Metabolic and Molecular Basis of Inherited Diseases. Diez- Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C. A glucose sensor hiding in a family of transporters. Proc Natl Acad Sci U S A. Elsas LJ, Rosenberg LE. Familial renal glycosuria: a genetic reappraisal of hexose transport by kidney and intestine. A novel SGLT2 mutation in a patient with autosomal recessive renal glucosuria. Nephrol Dial Transplant. Francis J, Zhang J, Farhi A, et al. A novel SGLT2 mutation in a patient with autosomal recessive renal glucosuria. Nephrol Dial Transplant. Na(+) - glucose transporter- 2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: involvement of hepatocyte nuclear factor- 1alpha expression and activity. Ganapathy V, Thangaraju M, Gopal E, Martin PM, Itagaki S, Miyauchi S, et al. Sodium- coupled monocarboxylate transporters in normal tissue and in cancer. Prevalence of glycosuria and diabetes mellitus. A comprehensive survey in an urban community. Hediger MA, Coady MJ, Ikeda TS, Wright EM. Expression cloning and c. DNA sequencing of the Na+/glucose co- transporter. Jackson WP, Marine N, Vinik AI. The significance of glycosuria. Development of tubular function. Kamran M, Peterson RG, Dominguez JH. Overexpression of GLUT2 gene in renal proximal tubules of diabetic Zucker rats. Kanai Y, Lee WS, You G, Brown D, Hediger MA. The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D- glucose. Glucose excretion in man and dog. Kloeckener- Gruissem B, Vandekerckhove K, N. Mutation of solute carrier SLC1. A1. 2 associates with a syndrome combining juvenile cataract with microcornea and renal glucosuria. Lee H, Han KH, Park HW, Shin JI, Kim CJ, Namgung MK. Familial renal glucosuria: a clinicogenetic study of 2. Loo DD, Wright EM, Zeuthen T. Nondiabetic melituria. Marble A, White P, Bradley RF, et al eds. Joslin's Diabetes Mellitus. Philadelphia, Pa: BC Decker Inc; 1. Oemar BS, Byrd DJ, Brodehl J. Complete absence of tubular glucose reabsorption: a new type of renal glucosuria (type 0). Oemar BS, Byrd DJ, Brodehl J. Complete absence of tubular glucose reabsorption: a new type of renal glucosuria (type 0). Cloning and functional expression of a mammalian Na+/nucleoside cotransporter. A member of the SGLT family. Brodehl J, Edelmann CM Jr, eds. Pediatric Kidney Disease. Little Brown & Co; 1. HNF1alpha controls renal glucose reabsorption in mouse and man. Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target. Clin J Am Soc Nephrol. Cell glucose transport and glucose handling during fetal and neonatal development. Rolin RA, Fox WW, eds. Fetal and Neonatal Physiology. Philadelphia, PA: WB Saunders Co; 1. The developing kidney and the process of growth. The Seldin DW, Giebisch G, eds. Kidney: Physiology and Pathophysiology. Wells RG, Pajor AM, Kanai Y, Turk E, Wright EM, Hediger MA. Cloning of a human kidney c. DNA with similarity to the sodium- glucose cotransporter. Woolf LI, Goodwin BL, Phelps CE. T- m- limited renal tubular reabsorption and the genetics of renal glucosuria. Wright EM, Hirayama BA, Loo DF. Active sugar transport in health and disease. Wright EM, Hirayama BA, Loo DF. Active sugar transport in health and disease. The sodium/glucose cotransport family SLC5. Transient renal glycosuria in a patient with acute pyelonephritis. Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M. Mutations in the hepatocyte nuclear factor- 1alpha gene in maturity- onset diabetes of the young (MODY3). Aminoaciduria and glycosuria. Barratt TM, Avner ED, Harmon WE, eds. Lippincott Williams & Wilkins; 1. Zhao X, Cui L, Lang U, Liu T, Lu J, Wang C, et al. A recurrent deletion in the SLC5. A2 gene including the intron 7 branch site responsible for familia renal glucosuria. Yu L, Xu Q, Hou P, Zhang H. Novel SLC5. A2 variants contribute to renal glucosuria in Chinese families: abnormal expression and dysfunction of variant SLC5. A2. Clinical and genetic analysis in a patient with primary renal glucosuria: Identification of a novel mutation in the SLC5. A2 gene. Ottosson- Laakso E, Tuomi T, Fors. Influence of Familial Renal Glycosuria Due to Mutations in the SLC5. A2 Gene on Changes in Glucose Tolerance over Time.
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Donald Trump is reportedly adding another member to his administration that wants to see the destruction of the program that they’ve been charged with leading. To link to this poem, put the URL below into your page: <a href="http:// of Myself by Walt Whitman</a> Plain for. Quentin Monge. The pattern work is great on these letterpress business cards. Created using white foil, these five colour letterpress business cards on triplex colourplan paper certainly pop. Using a bold and colourful pattern only plays to the card's strengths that'll certainly make for a memorable exchange. Designed by Don't Try Studio for Quentin Monge, they're some of the best looking we've ever seen. The Fox Yards Company. D embossed design makes its mark. Produced by Jukebox Print, these ultra thick cotton paper letterpress business cards bring 3. D embossed design to the table. Using Jukebox Print's own innovative method, the attention to detail is wonderful, with the letterpress used to add text as well as a quirky textured background. Christina Yan. A sophisticated letterpress option from Belinda Love Lee. Each piece was letterpressed with the finishing touches of gold foiling, gold edging, and embossing. ![]() ![]() OF ZOOSThe cards were designed for Designed for Singaporean online literary journal, OF ZOOSUsing a simple yet effective pattern of illustrative animals, these letterpress business cards pack a punch when it comes to originality. Designed for Singaporean online literary journal, OF ZOOS, we love designer Charmaine Yeo's execution. Rafal Borek Photography. The historic press was used for this business card design. The Letter & Press Behance page states: . Rafal from Ireland needed some business cards for his photographic business. But not a usual ones – really wonderful and over the top. So we printed the graphic with our historic press which can really show fine detail. For this of course one need the necessary know- how but after so many hundreds of thousands of business cards taken from the press job fits well in the hands – that you can be sure. Mild Whistle. Beautiful letterpress buisness cards for a Singapore based agency. Combining craft and precision to produce a beautiful aesthetic, these new cards from Singapore based agency Oddds are about as beautiful as they come. The Oddds website states: . This is created with the intertwining between bronze and a soft tone of turquoise. The play of metal tones and pieces with cotton represents the designer's ideologies of art direction and design. Elias Mendoza. These classic- looking cards aim to convey the unique and personalised touch that Mendoza brings to his work. When Cocoa Branding was hired to create branding materials for Elias Mendoza, one of the most prominent immigration and naturalisation attorneys in the United States, it needed to convey the unique and personalised touch that Mendoza brings to his work with all types of family and business immigration needs. Part of the branding solution was these heavyweight letterpress business cards, designed by Rodrigo Su. Bailey H Robinson. Two Arms Inc aimed for a turn- of- the- century look with this card, and got it spot on. Brooklyn- based tattoo artist Bailey H Robinson has a very distinct take on traditional American tattooing, and when he brought in Two Arms Inc to produce a set of custom letterpress business cards, they were keen to design something that looked and felt like traditional turn- of- the- century type. The resulting card is an ornate delight that wouldn't have looked out of place in 1. URL, of course). 1. Two Sisters Photography. Each sister has her own individual design to go with the striking main design. Commissioned to create an identity for Two Sisters Photography, Fizz took inspiration from a Venn diagram and used that as the basis for cameo- style silhouettes. The silhouettes enabled Fizz to showcase each sister's style and personality through their profile treatment, and alongside the Venn- style card Fizz also created individual designs for each sister. Fizz went all- out in the production stakes, using three Pantone colours on 2. Crane Letra cotton stock, and finishing everything off with a custom die- cut. Mia Parcell. Typographer Mia Parcell gets a circular letterpress card. Impressworks printed these letterpress business cards for designer Mia Parcell. The job features a two- colour, double- sided print on our 6. Fluoro White Crane Lettra stock. Parcell took care of the artwork herself, with Impressworks coming up with the circular execution. Simon Featherstone. A contemporary logo design and letterpress card for the lighting designer. Simon Featherstone is a freelance lighting designer and programmer, with vast experience in video and LED technology. He needed a branding refresh to help portray the qualities and capabilities of his practice to a wider audience. The contemporary logo marque used a pattern derived from LEDs and combined it with a bold gradient running from cyan to magenta. The branding collateral uses a range of cool grey tones to suitably reflect the high- end nature of the industry and communicate a professional and knowledgable tone of voice. Graphic Wand. Simple typography helps make this card design a winner. Marilyne Scheepers created this letterpress business card design for Graphic Wand studio. The turquoise colouring on the edge of the cards enables a striking effect when staked. Simple typography and a clever logo allow these letterpress business cards to speak for themselves. Combining authentic design with passionate craftsmenship. Offizin Parnassia is a fine art studio born out of a love for old books. The team there combined authentic design with passionate craftsmenship to create these beautiful Adicto letterpress business cards. Lucky Cat Acupuncture. A adorable anime influenced letterpress business card. This playful letterpress business card was created as part of the identity for designer Lovely Mpls' wife's acupuncture clinic in Minneapolis. The business cards were printed at Studio on Fire. Pepelatz. Andrej Barmelaj developed these postage- stamp inspired letterpress business cards for advertising agency Pepelatz. Ukraine- based designer and illustrator Andrej Barmelaj is the man behind these brilliant postage stamp- inspired letterpress business cards for independent advertising agency Pepelatz. With four different designs to choose from, each stamp adds a splash of colour to Pepelatz employees otherwise simple white letterpress business card. German Torres. Letterpress business cards for illustrator German Torres feature his character transforming from human to werewolf. These beautiful letterpress business cards feature the wild illustrator German Torres transforming from human to werewolf. Print shop La Trasteria created them using a two colour split fountain for the transformation and black ink for the other details. These creative business cards are beautifully printed, and we just love the playful design, which depicts a smiley character by day and the stages that turn him into a wild illustrator by night. Dane Holmquist. American artist Dane Holmquist created the illustration for these letterpress business cards himself. These detailed, beautiful letterpress business cards belong to illustrator and graphic designer Dane Holmquist. The talented artist created the intricate illustration himself, before elisting the help of printers DSJ in Santa Monica, who helped bring his vision to life. Holmquist's mantra is: . Jee. 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